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Individual differences in genetic variants of the thiamine-dependent proteins, in combination with environmental factors, may underlie personal vulnerabilities to thiamine deficiency, manifesting in an ever-increasing variety of clinical presentations

Likewise, decreased gene expression of Egr was evident at 24 h in the inferior caval vein, Vegfr expression was decreased at 1 h and 24 h in all vessels, and Plc gene expression was decreased at 24 h in the inferior caval vein

References Barbieri M, Bonafe M, Franceschi C, Paolisso G

3.7 Regulation of the PI3K/AKT/mTOR pathway The PI3K/AKT/mTOR signaling axis is a critical regulator of key cellular functions, including proliferation, metabolism, survival, and immune regulation (Jiang et al., 2020)